VIP
Last reviewed June 3, 2026
Also known as: Vasoactive Intestinal Peptide, Vasoactive Intestinal Polypeptide
Quick Answer
VIP is a neuropeptide research compound (not FDA-approved for human use) studied for systemic anti-inflammation. VIP is a naturally occurring neuropeptide that powerfully suppresses systemic inflammation, dilates blood vessels, and is the cornerstone treatment in the Shoemaker protocol for mold/biotoxin illness (CIRS). Research dose: 50–50 mcg 4x daily. Half-life: 2 minutes. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mg1Bio Longevity Labs Best $/mg
$63.72
$74.97Save $11.25
5mg vial
$14.99/mg
99%+ purityTested May 2026
Use code for 15% off:
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Rankings independent · Research use only
28-amino acid neuropeptide that binds VPAC1 and VPAC2 receptors, activating cAMP pathways to produce broad anti-inflammatory effects. Inhibits TNF-alpha, IL-6, and IL-12 production while promoting Th2
Where to Buy VIP
COA-verified vendors · Use code PEPTIDEX for up to 20% off
* Prices for research peptide acquisition. Not therapeutic products.
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
Bio Longevity LabsTriple-Tested | 99%+ | $74.975 mg | $63.72Save 15% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
Bio Longevity LabsTriple-Tested
$74.97 · 5 mg$63.72−15%
Use code PEPTIDEX for 15% off at Bio Longevity Labs.
* Research vendor — verify your regional regulations before purchase.
Shop at Bio Longevity Labs§ Mechanism of Action
28-amino acid neuropeptide that binds VPAC1 and VPAC2 receptors, activating cAMP pathways to produce broad anti-inflammatory effects. Inhibits TNF-alpha, IL-6, and IL-12 production while promoting Th2/Treg tolerance. Potent pulmonary vasodilator and bronchodilator. Used in the Shoemaker CIRS protocol for Chronic Inflammatory Response Syndrome (biotoxin illness) to correct TGF-beta 1 dysregulation and restore immune homeostasis.
§ Primary Benefits
- 1Systemic anti-inflammation
- 2CIRS/mold illness treatment
- 3pulmonary vasodilation
- 4immune modulation
§ Clinical Evidence
VIP is an autocrine growth factor for normal lung epithelium and as a growth factor and vasoactive compound for inflammatory conditions
Shoemaker et al.: Documents the use of intranasal VIP in CIRS patients, demonstrating normalization of TGF-beta 1, MMP-9, and VEGF, and improvement in pulmonary arterial pressure and NeuroQuant brain imaging abnormalities.
EmergingVasoactive intestinal peptide inhibits TLR4-induced inflammatory signaling in macrophages
Delgado et al.: VIP potently inhibits TLR4-mediated NF-kB activation and subsequent cytokine production (TNF-alpha, IL-6, IL-12) in macrophages, establishing its role as an endogenous immunomodulator.
Preclinical§ Safety Profile
Not FDA-approved for general use. Used in the Shoemaker CIRS protocol under practitioner supervision. Very short plasma half-life (~2 min). Should only be used after completing prior CIRS treatment steps. May cause facial flushing and hypotension at higher doses.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteNasal
Dose Range50–50 mcg
Frequency4x daily
TimingEvery 3-6 hours, intranasal
Cycle Length4–12 weeks
Shoemaker CIRS protocol: 50mcg intranasal 4x daily. Must complete prior protocol steps (cholestyramine, VCS correction, etc.) before initiating VIP.
§ Pharmacokinetics
⏱️ Half-Life: 2min
Plasma concentration over time§ Expected Outcomes
Week 1
Flushing adaptation; early TGF-beta 1 reduction
Weeks 2–4
Pulmonary arterial pressure improvement; reduced fatigue
Month 2–3
Normalization of inflammatory markers; cognitive improvement in CIRS
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Facial flushing | ~25% | mild |
Hypotension | ~10% | mild |
Nasal irritation | ~8% | mild |
Where to Source VIP for Research
Finding verified, high-purity VIP requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified VIP✓ Third-party tested·✓ US shipping·✓ COA on every batch
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Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
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