Synapsin
Last reviewed June 3, 2026
Also known as: Intranasal Synapsin, RG3 + NAD+ compound
Quick Answer
Synapsin is a nootropic peptide research compound (not FDA-approved for human use) studied for cognitive enhancement. Synapsin is a compounded intranasal cognitive blend (Rg3 + NAD+) used by functional medicine practitioners for brain fog, TBI recovery, and cognitive enhancement. It's a compound formulation, not a single peptide. Research dose: 100–200 mcg daily. Half-life: not established. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mgSourcing data for Synapsin is updating.
We verify new listings weekly — check back soon.
Where to Source
Ranked by $/mgSourcing data for Synapsin is updating.
We verify new listings weekly — check back soon.
Compounded intranasal formulation (not a single peptide) combining Rg3 (ginsenoside), NAD+, and additional neuroprotective compounds. Rg3 modulates NMDA and GABA receptor activity, reduces neuroinflam
Where to Buy Synapsin
COA-verified vendors · Use code PEPTIDEX for up to 20% off
Verified pricing for Synapsin is not yet available in our database. Browse all COA-verified vendors on our price comparison tool, or check individual vendor pages.
Compare All Vendors§ Mechanism of Action
Compounded intranasal formulation (not a single peptide) combining Rg3 (ginsenoside), NAD+, and additional neuroprotective compounds. Rg3 modulates NMDA and GABA receptor activity, reduces neuroinflammation via NF-kB inhibition, and promotes BDNF expression. NAD+ component supports mitochondrial function and sirtuin activation. Intranasal delivery bypasses blood-brain barrier. Often used in TBI, post-COVID cognitive impairment, and neurodegenerative disease support protocols.
§ Primary Benefits
- 1Cognitive enhancement
- 2neuroprotection
- 3mitochondrial function
- 4synaptic plasticity
§ Clinical Evidence
§ Safety Profile
Research only. Compounded intranasal formulation — individual components (Rg3, NAD+) have some published safety data but the specific compound blend lacks clinical trial validation. Not FDA-approved. Used in functional medicine under practitioner supervision.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteNasal
Dose Range100–200 mcg
FrequencyDaily
TimingMorning
Compounded intranasal formulation; dosing varies by compounding pharmacy formulation. Rg3 typically 0.5–1mg per dose. Research use only.
§ Expected Outcomes
Week 1
Acute cognitive effects reported; improved focus and mental clarity
Weeks 2–4
Neuroinflammation reduction in clinical observations
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Nasal irritation | ~10% | mild |
Mild headache | ~5% | mild |
Where to Source Synapsin for Research
Finding verified, high-purity Synapsin requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified Synapsin✓ Third-party tested·✓ US shipping·✓ COA on every batch
Disclosure: PeptiDex may earn a commission from purchases made through affiliate links. This does not affect our editorial independence or recommendations. We exclusively feature vendors that pass our strict quality verification protocols.
PEPTIDEX coupon for SynapsinSave 20% on Synapsin at Amino Club & verified vendors →
Reconstitution CalculatorCalculate reconstitution for Synapsin →
Compare ToolCompare Synapsin to similar peptides →
Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
Free Download
2026 Peptide Stack Cheat Sheet
12stacks • exact dosages • cycle lengths • printable reference
No spam. Unsubscribe anytime.
§ About the Author Verified
PeptiDex Research
Independent researcher, not a medical professional
PeptiDex Research is the byline used by the independent researcher who builds and maintains PeptiDex. The site is a one-person research project — there is no editorial board, no medical reviewers, and no clinical staff. Content is produced by reading...
View profileLast fact-checked: · PeptiDex Editorial Team