SS-31
Last reviewed June 3, 2026
Also known as: Elamipretide, Bendavia, MTP-131
Quick Answer
SS-31 is a mitochondrial peptide research compound (not FDA-approved for human use) studied for energy. SS-31 (Elamipretide) is a mitochondria-targeting peptide studied for protecting heart and muscle cells from energy failure, currently in FDA Fast Track development for heart failure. Research dose: 4–4 mg 7x/wk. Half-life: 4 hours. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mgSourcing data for SS-31 is updating.
We verify new listings weekly — check back soon.
Where to Source
Ranked by $/mgSourcing data for SS-31 is updating.
We verify new listings weekly — check back soon.
Mitochondrial protection. Selectively concentrates in the inner mitochondrial membrane where it stabilizes cardiolipin for efficient electron transport chain function.
Where to Buy SS-31
COA-verified vendors · Use code PEPTIDEX for up to 20% off
* Prices for research peptide acquisition. Not therapeutic products.
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
| 98%+ | $75.0010 mg | $37.50Save 50% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
$75.00 · 10 mg$37.50−50%
Use code PEPTIDEX for 50% off at Ascension Peptides.
* Research vendor — verify your regional regulations before purchase.
Shop at Ascension Peptides§ Mechanism of Action
Mitochondrial protection. Selectively concentrates in the inner mitochondrial membrane where it stabilizes cardiolipin for efficient electron transport chain function.
§ Primary Benefits
- 1Energy
- 2recovery
- 3neuroprotection
§ Clinical Evidence
SS-31 (Elamipretide) clinical trials overview
Szeto (Br. J. Pharmacol.): Comprehensive review of elamipretide mechanism and clinical trial results in heart failure, mitochondrial myopathy, and ischemia-reperfusion injury.
ModerateElamipretide stabilizes cardiolipin and cristae structure
Birk et al. (Pharmaceuticals): Detailed mechanism review showing elamipretide binds cardiolipin, stabilizes mitochondrial cristae, reduces ROS, and improves oxidative phosphorylation.
PreclinicalElamipretide attenuates age-related cardiac protein modifications
Study demonstrating elamipretide can reverse age-associated post-translational heart protein modifications, restoring mitochondrial function in aged cardiac tissue.
PreclinicalElamipretide improves mitochondrial dysfunction and memory impairment
SS-31 improves LPS-induced mitochondrial dysfunction, oxidative stress, and memory impairment in mice via BDNF signaling regulation.
PreclinicalElamipretide rescues muscle force and cardiac function in aging
Treatment improves ADP sensitivity in aged mitochondria by increasing ANT uptake, rescuing skeletal muscle force and cardiac systolic function.
PreclinicalComprehensive dry eye therapy: overcoming ocular surface barrier and combating inflammation, oxidation, and mitochondrial damage.
A study published in Journal of nanobiotechnology investigating the effects and mechanisms.
PreclinicalEffect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA-HCM.
A study published in Journal of the American College of Cardiology investigating the effects and mechanisms.
PreclinicalReprogramming of Treg cell-derived small extracellular vesicles effectively prevents intestinal inflammation from PANoptosis by blocking mitochondrial oxidative stress.
A study published in Trends in biotechnology investigating the effects and mechanisms.
PreclinicalSS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease.
A study published in Oxidative medicine and cellular longevity investigating the effects and mechanisms.
PreclinicalElamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization.
A study published in Journal of neuroinflammation investigating the effects and mechanisms.
Preclinical§ Safety Profile
Well-tolerated in multiple Phase 2/3 trials. Granted Fast Track and Orphan Drug designations by FDA.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range4000–4000 mcg
Frequency7x/wk
TimingMorning
Cycle Length4–4 weeks
BAC Water2.5 ml / 10mg vial
Clinical trial doses: 4-40mg SubQ daily. Higher doses for cardiac indications.
§ Pharmacokinetics
⏱️ Half-Life: 4h
Plasma concentration over time§ Regulatory
🇺🇸USA
Investigational🇨🇦Canada
Investigational🇬🇧UK
Investigational🇪🇺EU
Investigational🇦🇺Australia
InvestigationalLast updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.
§ Expected Outcomes
Week 1
Improved mitochondrial efficiency; reduced exercise-induced oxidative stress
Weeks 2–4
Improved exercise capacity and recovery; reduced fatigue
Month 2–3
Cardioprotective adaptations; improved VO2 markers in clinical trials
Long-term
Sustained mitochondrial protection; FDA Fast Track designation for cardiac indications
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Well-tolerated in Phase 2/3 trials | No serious adverse events reported | mild |
Injection site reaction | ~5% of users | mild |
Where to Source SS-31 for Research
Finding verified, high-purity SS-31 requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified SS-31✓ Third-party tested·✓ US shipping·✓ COA on every batch
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Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
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