Sermorelin
Last reviewed June 3, 2026
Quick Answer
Sermorelin is a ghrh analog research compound (not FDA-approved for human use) studied for muscle growth. Sermorelin is a GHRH analog previously FDA-approved for diagnosing GH deficiency in children, studied for restoring natural growth hormone secretion in adults without suppressing the GH axis. Research dose: 300–300 mcg 7x/wk. Half-life: 12 minutes. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mgSourcing data for Sermorelin is updating.
We verify new listings weekly — check back soon.
Where to Source
Ranked by $/mgSourcing data for Sermorelin is updating.
We verify new listings weekly — check back soon.
Natural GH pulse stimulation. Mimics endogenous GHRH to stimulate the pituitary gland's own growth hormone production in a physiologic, pulsatile pattern.
Where to Buy Sermorelin
COA-verified vendors · Use code PEPTIDEX for up to 20% off
* Prices for research peptide acquisition. Not therapeutic products.
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
| 98%+ | $85.0010 mg | $42.50Save 50% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
$85.00 · 10 mg$42.50−50%
Use code PEPTIDEX for 50% off at Ascension Peptides.
* Research vendor — verify your regional regulations before purchase.
Shop at Ascension Peptides§ Mechanism of Action
Natural GH pulse stimulation. Mimics endogenous GHRH to stimulate the pituitary gland's own growth hormone production in a physiologic, pulsatile pattern.
§ Primary Benefits
- 1Muscle growth
- 2recovery
- 3sleep
- 4anti-aging
§ Clinical Evidence
Sermorelin increases lean mass in older adults
Vittone et al.: Sermorelin treatment significantly increases lean body mass, improves body composition, and enhances GH/IGF-1 levels in older adults.
Moderate-StrongSermorelin for idiopathic GH deficiency in children (FDA study)
Prakash & Garg: FDA-approved indication sermorelin produces significant and sustained height velocity increases in prepubertal children with GH deficiency.
StrongSermorelin restores GH and IGF-1 in aging men
Veldhuis et al. (J. Clin. Endocrinol. Metab.): Demonstrates sermorelin injections effectively restore GH and IGF-1 levels in older men with age-related GH decline.
Moderate-StrongSermorelin gender-specific anabolic responses
Study examining sermorelin's ability to stimulate GH/IGF-1 secretion in men and women, identifying gender-specific anabolic benefits and dosing considerations.
ModerateCationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples.
A study published in Analytical biochemistry investigating the effects and mechanisms.
PreclinicalGrowth Hormone-Releasing Hormone Antagonists Increase Radiosensitivity in Non-Small Cell Lung Cancer Cells.
A study published in International journal of molecular sciences investigating the effects and mechanisms.
PreclinicalIn-house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH-related peptides.
A study published in Biomedical chromatography : BMC investigating the effects and mechanisms.
PreclinicalA potentially effective drug for patients with recurrent glioma: sermorelin.
A study published in Annals of translational medicine investigating the effects and mechanisms.
ModerateGrowth hormone releasing hormone.
A study published in Clinics in endocrinology and metabolism investigating the effects and mechanisms.
PreclinicalProbing for peptidic drugs (2-10 kDa) in doping control blood samples.
A study published in Analytical science advances investigating the effects and mechanisms.
Preclinical§ Safety Profile
Very safe; mimics physiology. Previously FDA-approved for GH deficiency diagnosis. Well-tolerated.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range300–300 mcg
Frequency7x/wk
TimingPre-bed
Cycle Length12–12 weeks
BAC Water2.5 ml / 2mg vial
Inject before bed for maximum GH pulse during sleep. Very short half-life = frequent dosing.
§ Pharmacokinetics
⏱️ Half-Life: 12min
Plasma concentration over time§ Regulatory
🇺🇸USA
Prescription Only🇨🇦Canada
Prescription Only🇬🇧UK
Unregulated🇪🇺EU
Unregulated🇦🇺Australia
Prescription OnlyLast updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.
§ Expected Outcomes
Week 1
Improved sleep depth; GH pulse enhancement during sleep
Weeks 2–4
Increased energy and recovery; some users report improved skin quality
Month 2–3
Body composition improvements; IGF-1 elevation on bloodwork
Long-term
Sustained GH axis support with physiologic (non-suppressive) mechanism
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Injection site reactions | ~8% of users | mild |
Headache | ~5% of users | mild |
Flushing | ~6% of users | mild |
Dizziness | ~3% of users | mild |
Where to Source Sermorelin for Research
Finding verified, high-purity Sermorelin requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified Sermorelin✓ Third-party tested·✓ US shipping·✓ COA on every batch
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§ Comparisons
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⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
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