PT-141
FDA ApprovedLast reviewed June 3, 2026
Also known as: Bremelanotide, Vyleesi
Quick Answer
PT-141 is a melanocortin agonist FDA-approved studied for sexual arousal. PT-141 (Bremelanotide) is an FDA-approved melanocortin agonist prescribed as Vyleesi for hypoactive sexual desire disorder in premenopausal women, also studied for male erectile dysfunction. Research dose: 1.50–1.50 mg 2x/wk. Half-life: 2.7 hours. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mg1Bio Longevity Labs Best $/mg
$40.77
$47.97Save $7.20
5mg vial
$9.59/mg
99%+ purityTested Apr 2026
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Rankings independent · Research use only
Central melanocortin pathway. Activates MC4R in the CNS to stimulate sexual desire through brain pathways rather than vascular effects.
Where to Buy PT-141
COA-verified vendors · Use code PEPTIDEX for up to 20% off
* Prices for research peptide acquisition. Not therapeutic products.
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
| 98%+ | $45.0010 mg | $22.50Save 50% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop | |
Bio Longevity LabsTriple-Tested | 99%+ | $47.975 mg | $40.77Save 15% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
$45.00 · 10 mg$22.50−50%
Use code PEPTIDEX for 50% off at Ascension Peptides.
* Research vendor — verify your regional regulations before purchase.
Shop at Ascension PeptidesBio Longevity LabsTriple-Tested
$47.97 · 5 mg$40.77−15%
Use code PEPTIDEX for 15% off at Bio Longevity Labs.
* Research vendor — verify your regional regulations before purchase.
Shop at Bio Longevity Labs§ Mechanism of Action
Central melanocortin pathway. Activates MC4R in the CNS to stimulate sexual desire through brain pathways rather than vascular effects.
§ Primary Benefits
- 1Sexual arousal
- 2libido
§ Clinical Evidence
PT-141 (Bremelanotide) for hypoactive sexual desire Phase 3
Kingsberg et al. (Obstet. & Gynecol.): Two identical Phase 3 RECONNECT trials showing bremelanotide significantly improves sexual desire and reduces distress in premenopausal women with HSDD.
Very StrongBremelanotide Phase 3 efficacy and safety in HSDD
Clayton et al.: Phase 3 data confirming statistically significant improvements in desire metrics with favorable safety profile (nausea, flushing, headache). Led to FDA approval.
Very StrongPT-141 induces erection in men with erectile dysfunction
Diamond et al.: Double-blind, placebo-controlled study showing PT-141 induces significant erectile response at >7mg doses, effective even in PDE5 inhibitor non-responders.
StrongBremelanotide mechanism of action and pharmacology review
Comprehensive review of bremelanotide's MC4R mechanism, pharmacokinetics, clinical trial efficacy, and safety data across male and female sexual dysfunction studies.
StrongStrategies for Treating Sexual Health Concerns After Breast and Gynecologic Cancer.
A 2025 review found that pharmacological agents like bremelanotide demonstrated efficacy for managing low sexual desire in breast and gynecologic cancer survivors. The analysis investigated multimodal treatment strategies, emphasizing the need for individualized care to address treatment-related sexual dysfunction.
ModerateGateways to clinical trials.
A study published in Methods and findings in experimental and clinical pharmacology investigating the effects and mechanisms.
ModerateGateways to clinical trials.
A study published in Methods and findings in experimental and clinical pharmacology investigating the effects and mechanisms.
ModerateGateways to clinical trials.
A study published in Methods and findings in experimental and clinical pharmacology investigating the effects and mechanisms.
ModerateGateways to clinical trials.
A study published in Methods and findings in experimental and clinical pharmacology investigating the effects and mechanisms.
ModerateGateways to clinical trials.
A study published in Methods and findings in experimental and clinical pharmacology investigating the effects and mechanisms.
Moderate§ Safety Profile
Nausea/hypertension possible. FDA-approved (Vyleesi) for HSDD in premenopausal women. Limited to 8 doses/month.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range1500–1500 mcg
Frequency2x/wk
Timing45 min before activity
BAC Water2.5 ml / 10mg vial
FDA-approved dose: 1.75mg SubQ as needed. Max 1 dose per 24h, 8 doses/month.
§ Pharmacokinetics
⏱️ Half-Life: 2.7h
Plasma concentration over time§ Regulatory
🇺🇸USA
FDA/TGA Approved🇨🇦Canada
Research Only🇬🇧UK
Unregulated🇪🇺EU
Unregulated🇦🇺Australia
Research OnlyLast updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.
§ Expected Outcomes
Week 1
Libido enhancement typically onset within 45 minutes of dosing
Weeks 2–4
Consistent improvement in sexual response and desire
Month 2–3
Psychological effects may plateau; effectiveness maintained with intermittent use
Long-term
FDA-approved for long-term use; limit to 8 doses/month
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Nausea From Phase 3 RECONNECT trial data | ~40% of users | moderate |
Flushing | ~20% of users | mild |
Headache | ~10% of users | mild |
Transient blood pressure increase Avoid if uncontrolled hypertension | ~8% of users | moderate |
Where to Source PT-141 for Research
Finding verified, high-purity PT-141 requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified PT-141✓ Third-party tested·✓ US shipping·✓ COA on every batch
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§ Comparisons
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