Klotho
Last reviewed June 3, 2026
Also known as: Alpha-Klotho, KL, Soluble Klotho, Klotho protein fragment
Quick Answer
Klotho is a anti-aging protein research compound (not FDA-approved for human use) studied for cognitive aging reversal. Klotho is a longevity protein that declines with age — mice injected with it show dramatically reversed cognitive aging within days. It regulates kidney health, brain function, and multiple cellular aging pathways. Research dose: 10–30 mcg single dose or pulsed quarterly (mouse/nhp study protocol). Half-life: 8 hours. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mgSourcing data for Klotho is updating.
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Where to Source
Ranked by $/mgSourcing data for Klotho is updating.
We verify new listings weekly — check back soon.
Klotho is a type-I transmembrane aging-suppressor protein expressed primarily in kidney tubular cells and brain choroid plexus. Cleaved extracellularly to generate soluble Klotho, which circulates sys
Where to Buy Klotho
COA-verified vendors · Use code PEPTIDEX for up to 20% off
Verified pricing for Klotho is not yet available in our database. Browse all COA-verified vendors on our price comparison tool, or check individual vendor pages.
Compare All Vendors§ Mechanism of Action
Klotho is a type-I transmembrane aging-suppressor protein expressed primarily in kidney tubular cells and brain choroid plexus. Cleaved extracellularly to generate soluble Klotho, which circulates systemically and acts as a co-receptor for FGF23, regulating phosphate and vitamin D metabolism. Also directly inhibits IGF-1 and Wnt signaling pathways that drive cellular senescence. Circulating Klotho declines dramatically with age. A single administration of soluble Klotho protein restored cognitive function in aged mice to levels of young adults within 2 weeks.
§ Primary Benefits
- 1Cognitive aging reversal
- 2kidney protection
- 3cardiovascular protection
- 4longevity
- 5FGF23 regulation
§ Clinical Evidence
Soluble Klotho reverses cognitive and synaptic aging
Castner et al. (Nature Aging): A single systemic injection of soluble Klotho protein significantly enhanced cognitive performance in aged nonhuman primates and mice, restoring working memory and synaptic plasticity to young-adult levels.
PreclinicalLow circulating Klotho is associated with cognitive decline and dementia
Semba et al.: Lower serum Klotho levels in community-dwelling adults are significantly associated with faster cognitive decline and increased dementia risk over longitudinal follow-up.
Emerging§ Safety Profile
⚠ EARLY-STAGE EXPERIMENTAL. Recombinant Klotho protein administration has not entered human clinical trials for anti-aging or cognitive enhancement. Klotho is a large protein (~130 kDa), not a classical peptide — reconstitution, stability, and route of administration for research use are complex. Research only.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteIV
Dose Range10–30 mcg
FrequencySingle dose or pulsed quarterly (mouse/NHP study protocol)
NHP study: single IV injection. No human dosing protocol. Recombinant protein administration requires specialized handling. Research only.
§ Pharmacokinetics
⏱️ Half-Life: 8h
Plasma concentration over time§ Expected Outcomes
Week 1
Cognitive improvement observed within 2 weeks in NHP models
Month 2–3
Sustained cognitive and synaptic plasticity improvements in animal models
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Unknown in humans No human clinical data available | Not established | rare |
Where to Source Klotho for Research
Finding verified, high-purity Klotho requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
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Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
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§ About the Author Verified
PeptiDex Research
Independent researcher, not a medical professional
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