Humanin
Last reviewed June 3, 2026
Also known as: HN, Humanin-G, S14G-Humanin
Quick Answer
Humanin is a mitochondrial peptide research compound (not FDA-approved for human use) studied for neuroprotection. Humanin is a tiny peptide made by your mitochondria that protects cells from dying, shields the brain from Alzheimer's plaques, and improves insulin sensitivity. Blood levels drop dramatically with age. Research dose: 50–200 mcg daily. Half-life: 30 minutes. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mgSourcing data for Humanin is updating.
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Where to Source
Ranked by $/mgSourcing data for Humanin is updating.
We verify new listings weekly — check back soon.
21-amino acid mitochondrial-derived peptide (MOTS-c sibling peptide) encoded in the 16S rRNA gene of mitochondrial DNA. Binds formyl peptide receptor-like 1 (FPRL1/FPR2) and the gp130 co-receptor comp
Where to Buy Humanin
COA-verified vendors · Use code PEPTIDEX for up to 20% off
Verified pricing for Humanin is not yet available in our database. Browse all COA-verified vendors on our price comparison tool, or check individual vendor pages.
Compare All Vendors§ Mechanism of Action
21-amino acid mitochondrial-derived peptide (MOTS-c sibling peptide) encoded in the 16S rRNA gene of mitochondrial DNA. Binds formyl peptide receptor-like 1 (FPRL1/FPR2) and the gp130 co-receptor complex, activating STAT3 and PI3K/Akt survival signaling. Potently inhibits Bax-mediated apoptosis, protects neurons against amyloid-beta toxicity, and improves insulin sensitivity. Circulating levels decline significantly with age.
§ Primary Benefits
- 1Neuroprotection
- 2anti-apoptosis
- 3insulin sensitization
- 4longevity
- 5Alzheimer's protection
§ Clinical Evidence
Humanin: a neuroprotective peptide against Alzheimer's disease
Hashimoto et al. (Nature): Discovery paper identifying Humanin as a secreted peptide from surviving neurons that protects against Alzheimer's disease-related insults including amyloid-beta toxicity and familial AD gene expression.
PreclinicalHumanin declines with age and is associated with age-related diseases
Muzumdar et al.: Demonstrates that circulating Humanin levels decline progressively with age in humans, and low levels are associated with increased cardiovascular disease risk and insulin resistance.
EmergingExogenous Humanin improves insulin sensitivity and reduces inflammation
Muzumdar et al.: Exogenous Humanin administration in rodents improves insulin sensitivity, reduces hepatic glucose production, and attenuates systemic inflammation, establishing its metabolic effects.
Preclinical§ Safety Profile
⚠ PRECLINICAL RESEARCH ONLY for therapeutic use. No completed human clinical trials for exogenous administration. Endogenous peptide with well-established biology; exogenous therapeutic use remains experimental. S14G-Humanin is a more potent synthetic analog.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range50–200 mcg
FrequencyDaily
No validated human dosing protocol. Rodent studies use 1–5mg/kg doses. Research use only.
§ Pharmacokinetics
⏱️ Half-Life: 30min
Plasma concentration over time§ Expected Outcomes
Weeks 2–4
Rodent models show neuroprotection and metabolic improvement within 4 weeks
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Unknown in humans No human safety data for exogenous administration | Not established | rare |
Where to Source Humanin for Research
Finding verified, high-purity Humanin requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified Humanin✓ Third-party tested·✓ US shipping·✓ COA on every batch
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Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
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§ About the Author Verified
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Independent researcher, not a medical professional
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