Gonadorelin
FDA ApprovedLast reviewed June 3, 2026
Also known as: GnRH, LHRH, Gonadorelin acetate, Factrel
Quick Answer
Gonadorelin is a gnrh analog FDA-approved studied for lh/fsh stimulation. Gonadorelin is a synthetic copy of the body's own GnRH hormone, used to keep the testes active and maintain natural testosterone production and fertility when someone is on testosterone replacement therapy. Research dose: 100–200 mcg 2x weekly. Half-life: 3 minutes. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mgSourcing data for Gonadorelin is updating.
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Where to Source
Ranked by $/mgSourcing data for Gonadorelin is updating.
We verify new listings weekly — check back soon.
Synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH). Binds GnRH receptors in the anterior pituitary, stimulating pulsatile release of luteinizing hormone (LH) and folli
Where to Buy Gonadorelin
COA-verified vendors · Use code PEPTIDEX for up to 20% off
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Compare All Vendors§ Mechanism of Action
Synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH). Binds GnRH receptors in the anterior pituitary, stimulating pulsatile release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Used in compounding to maintain testicular function, prevent atrophy, and preserve fertility during exogenous testosterone therapy. Pulsatile dosing is critical — continuous administration causes downregulation.
§ Primary Benefits
- 1LH/FSH stimulation
- 2testosterone preservation
- 3HPG axis support during TRT
- 4fertility support
§ Clinical Evidence
Pulsatile GnRH treatment restores gonadotropin secretion and fertility
Leyendecker et al.: Pulsatile GnRH administration effectively restores LH/FSH pulsatility and fertility in hypogonadotropic hypogonadism patients, establishing the pulsatile dosing principle.
StrongGonadorelin preserves intratesticular testosterone and spermatogenesis during testosterone replacement
Hsieh et al.: Low-dose hCG (mechanistically analogous to gonadorelin for LH stimulation) maintains intratesticular testosterone and sperm production during TRT, demonstrating the principle underlying gonadorelin co-administration.
Moderate§ Safety Profile
FDA-approved as Factrel (historical, for diagnostic testing of HPG axis). Compounded gonadorelin used as TRT adjunct is not itself FDA-approved for this indication. Very short half-life requires frequent dosing. Continuous infusion causes pituitary desensitization and is counterproductive.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range100–200 mcg
Frequency2x weekly
TimingPulsatile — 2–3 times per week
Compounded TRT adjunct protocol: 100–200mcg SubQ 2–3x/week. Pulsatile dosing is essential. Continuous use causes desensitization. Research/compounding use only.
§ Pharmacokinetics
⏱️ Half-Life: 3min
Plasma concentration over time§ Expected Outcomes
Week 1
LH/FSH pulse restoration within hours of first dose
Weeks 2–4
Testicular volume maintenance; intratesticular testosterone preservation
Month 2–3
Spermatogenesis maintained if used consistently alongside TRT
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Injection site reaction | ~10% | mild |
Headache | ~5% | mild |
Nausea | ~3% | mild |
Where to Source Gonadorelin for Research
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⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
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