Glutathione

Forman et al. (Mol. Aspects Med.): Comprehensive review of glutathione's role in redox signaling, detoxification, and its depletion in disease states including Parkinson's, liver disease, and cancer.

Dröge & Breitkreutz (Proc. Nutr. Soc.): Review demonstrating glutathione's critical role in lymphocyte proliferation, NK cell activity, and overall immune defense.

Weschawalit et al. (Clin. Cosmet. Investig. Dermatol.): RCT showing oral glutathione supplementation significantly reduces melanin index and improves skin elasticity and wrinkles.

Sian et al.: Early landmark study demonstrating reduced glutathione levels as one of the earliest biochemical changes in Parkinson's disease pathology.

A 2026 study found that extracellular vesicles from human umbilical cord mesenchymal stem cells reduced pulmonary fibrosis and ferroptosis in a mouse model. Researchers demonstrated this effect was driven by USP10-mediated deubiquitination and stabilization of the SLC7A11 protein.

A 2026 study demonstrated that NAD+ administration significantly attenuated lung injury following cardiac arrest and resuscitation in a swine model. Researchers found this effect was likely mediated by suppressing ferroptosis through the modulation of the YAP/ACSL4 signaling pathway.

A 2026 preclinical study demonstrated that DOPA-31 mitigated cadmium-induced neurotoxicity in a zebrafish model by reducing oxidative stress and downregulating pro-inflammatory markers. Researchers found the derivative improved motor and cognitive functions while upregulating neuroprotective factors and reducing neuronal damage.

In a 2026 preclinical study, researchers demonstrated that vaccarin alleviated myocardial ischemia-reperfusion injury in mouse and cellular models. The findings indicated that vaccarin suppressed oxidative stress and ferroptosis by inhibiting the NOX4-driven JAK2/STAT3 signaling pathway.

A 2026 study demonstrated that ZFP36L1 promotes microglial ferroptosis and neuroinflammation during ischemic stroke by reducing FTO mRNA stability and increasing ACSL1 expression. Researchers found that silencing ZFP36L1 successfully alleviated cerebral ischemic injury in mouse models.

Targeting ferroptosis exploits metabolic vulnerabilities in breast cancer subtypes and influences the tumor microenvironment, a 2026 review found. The research demonstrated that this iron-dependent cell death mechanism provides a potential strategy to address drug-resistant cancer stem cells.