FOXO4-DRI
Last reviewed June 3, 2026
Also known as: FOXO4-D-Retro-Inverso, Senolytic peptide
Quick Answer
FOXO4-DRI is a senolytic peptide research compound (not FDA-approved for human use) studied for senescent cell elimination (senolytics). FOXO4-DRI is a senolytic peptide that forces senescent ('zombie') cells to undergo programmed death by breaking the survival signal that keeps them alive, studied in mice for tissue rejuvenation and reversal of aging markers. Research dose: 5–10 mg pulsed — 3 days per week, per mouse study protocol. Half-life: 2 hours. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mg1Bio Longevity Labs Best $/mg
$233.72
$274.97Save $41.25
10mg vial
$27.50/mg
99%+ purityTested May 2026
Use code for 15% off:
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Rankings independent · Research use only
D-retro-inverso peptide that disrupts the interaction between FOXO4 and p53 in senescent cells. In normal cells, FOXO4 retains p53 in the nucleus preventing apoptosis — a mechanism senescent cells exp
Where to Buy FOXO4-DRI
COA-verified vendors · Use code PEPTIDEX for up to 20% off
* Prices for research peptide acquisition. Not therapeutic products.
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
Bio Longevity LabsTriple-Tested | 99%+ | $274.9710 mg | $233.72Save 15% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
Bio Longevity LabsTriple-Tested
$274.97 · 10 mg$233.72−15%
Use code PEPTIDEX for 15% off at Bio Longevity Labs.
* Research vendor — verify your regional regulations before purchase.
Shop at Bio Longevity Labs§ Mechanism of Action
D-retro-inverso peptide that disrupts the interaction between FOXO4 and p53 in senescent cells. In normal cells, FOXO4 retains p53 in the nucleus preventing apoptosis — a mechanism senescent cells exploit for survival. FOXO4-DRI competitively binds FOXO4, freeing p53 to migrate to mitochondria, triggering apoptosis selectively in senescent cells. Results in clearance of senescent cell burden, reduction of the senescence-associated secretory phenotype (SASP), and tissue rejuvenation markers in aged mice.
§ Primary Benefits
- 1Senescent cell elimination (senolytics)
- 2longevity
- 3tissue rejuvenation
- 4SASP reduction
§ Clinical Evidence
§ Safety Profile
⚠ EXPERIMENTAL COMPOUND. NO HUMAN CLINICAL TRIALS. Mechanism is potent and irreversible (apoptosis induction). Selective for senescent cells in mouse models but human selectivity profiles are unknown. Aggressive Herxheimer-like inflammatory response from SASP release possible during senescent cell clearance. DO NOT USE without comprehensive medical supervision.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range5000–10000 mcg
FrequencyPulsed — 3 days per week, per mouse study protocol
Cycle Length3–3 weeks
Mouse study: 10mg/kg IP 3x/week. No validated human protocol. Human equivalent dose extrapolation is not clinically validated.
§ Pharmacokinetics
⏱️ Half-Life: 2h
Plasma concentration over time§ Expected Outcomes
Week 1
Senescent cell clearance begins; possible SASP-driven inflammatory response
Weeks 2–4
Tissue rejuvenation markers in mouse models (fur density, fitness scores)
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
SASP inflammatory response Transient cytokine surge from dying senescent cells | Unknown in humans | moderate |
Unknown off-target apoptosis Selective for senescent cells in mouse models; human selectivity uncharacterized | Unknown | rare |
Where to Source FOXO4-DRI for Research
Finding verified, high-purity FOXO4-DRI requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
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Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
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