FGL Loop
Last reviewed June 3, 2026
Also known as: NCAM FGL peptide, Fibroblast Growth Factor Loop, FGL
Quick Answer
FGL Loop is a neurotropic peptide research compound (not FDA-approved for human use) studied for synaptogenesis. FGL is a peptide that mimics NCAM — the brain's cell-to-cell communication molecule — to trigger synapse formation and improve memory in rodent models by activating the same growth factor pathways. Research dose: 1–5 mg daily. Half-life: not established. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mgSourcing data for FGL Loop is updating.
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Where to Source
Ranked by $/mgSourcing data for FGL Loop is updating.
We verify new listings weekly — check back soon.
Synthetic peptide derived from the fibronectin type III (F3) module of Neural Cell Adhesion Molecule (NCAM). Mimics the homophilic binding of NCAM, activating FGFR (fibroblast growth factor receptor)
Where to Buy FGL Loop
COA-verified vendors · Use code PEPTIDEX for up to 20% off
Verified pricing for FGL Loop is not yet available in our database. Browse all COA-verified vendors on our price comparison tool, or check individual vendor pages.
Compare All Vendors§ Mechanism of Action
Synthetic peptide derived from the fibronectin type III (F3) module of Neural Cell Adhesion Molecule (NCAM). Mimics the homophilic binding of NCAM, activating FGFR (fibroblast growth factor receptor) signaling downstream, which promotes synaptogenesis, long-term potentiation (LTP), and memory consolidation. In rodent models improves spatial memory and reduces age-related synaptic loss.
§ Primary Benefits
- 1Synaptogenesis
- 2memory enhancement
- 3NCAM-mediated neuroprotection
§ Clinical Evidence
FGL peptide promotes synaptogenesis and memory via NCAM/FGFR signaling
Cambon et al.: FGL peptide enhances LTP in hippocampal slices and improves spatial learning in rodents via FGFR-dependent synaptogenesis, establishing NCAM-mimetic peptides as cognitive enhancers.
PreclinicalNCAM mimetics as neuroprotective agents in aging and neurodegeneration
Review of NCAM-derived peptides including FGL, documenting their capacity to promote synaptogenesis, neuroprotection, and memory retention in animal models of aging and neurodegeneration.
Preclinical§ Safety Profile
⚠ PRECLINICAL RESEARCH ONLY. No completed human clinical trials. All data from rodent models. No established human pharmacokinetics, dosing protocol, or safety profile. Research use only.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range1000–5000 mcg
FrequencyDaily
Rodent study doses only. No validated human protocol. Research use only.
§ Expected Outcomes
Weeks 2–4
Synaptic density and memory improvements in rodent models
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Unknown in humans No human safety data | Not established | rare |
Where to Source FGL Loop for Research
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Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
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§ About the Author Verified
PeptiDex Research
Independent researcher, not a medical professional
PeptiDex Research is the byline used by the independent researcher who builds and maintains PeptiDex. The site is a one-person research project — there is no editorial board, no medical reviewers, and no clinical staff. Content is produced by reading...
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