Dihexa
Last reviewed June 3, 2026
Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408
Quick Answer
Dihexa is a neurotropic peptide research compound (not FDA-approved for human use) studied for synaptogenesis. Dihexa is a brain-penetrating peptide from Washington State University research that triggers new synapse formation at extremely low doses — it's been called millions of times more potent than BDNF for this effect in rodent models. Research dose: 5–20 mcg infrequent (2-3x per week due to long half-life). Half-life: 2 days. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mgSourcing data for Dihexa is updating.
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Where to Source
Ranked by $/mgSourcing data for Dihexa is updating.
We verify new listings weekly — check back soon.
Angiotensin IV analog developed at Washington State University. Binds hepatocyte growth factor (HGF) and potentiates its binding to the c-Met receptor, triggering downstream synaptogenesis cascades in
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Compare All Vendors§ Mechanism of Action
Angiotensin IV analog developed at Washington State University. Binds hepatocyte growth factor (HGF) and potentiates its binding to the c-Met receptor, triggering downstream synaptogenesis cascades in hippocampal neurons. Reported to be 7 orders of magnitude more potent than BDNF for synaptic formation in vitro. Crosses blood-brain barrier and is orally bioavailable. Produces dose-dependent improvements in spatial memory in rodent models of cognitive impairment.
§ Primary Benefits
- 1Synaptogenesis
- 2memory enhancement
- 3cognitive repair
- 4angiotensin IV activity
§ Clinical Evidence
Dihexa promotes synaptogenesis and cognitive function in rodents
McCoy et al. (Journal of Pharmacology & Experimental Therapeutics): Dihexa produces dose-dependent improvements in spatial learning in rodent water maze models and promotes dendritic spine density via HGF/c-Met synaptogenesis signaling.
PreclinicalAngiotensin IV analogs and HGF/c-Met signaling in memory
Wright et al.: Establishes the mechanistic basis for angiotensin IV analog activity at HGF and c-Met, demonstrating memory-enhancing and neuroprotective downstream effects.
Preclinical§ Safety Profile
⚠ PRECLINICAL RESEARCH ONLY. No completed human clinical trials. No established human safety profile. Extreme potency suggests very low effective doses but also potential for off-target effects. Do not use without full understanding of preclinical literature.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteOral
Dose Range5–20 mcg
FrequencyInfrequent (2-3x per week due to long half-life)
Rodent effective doses in the ng/kg range. Human equivalent extrapolations suggest mcg-level doses. No validated human protocol. Oral bioavailability documented in rodents.
§ Pharmacokinetics
⏱️ Half-Life: 2d
Plasma concentration over time§ Expected Outcomes
Weeks 2–4
Memory and learning improvements in rodent models
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Unknown in humans No human safety data | Not established | rare |
Where to Source Dihexa for Research
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Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
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