Cortagen
Last reviewed June 3, 2026
Also known as: Ala-Glu-Asp-Pro, AEDP
Quick Answer
Cortagen is a khavinson peptide research compound (not FDA-approved for human use) studied for neuroregeneration. Cortagen is a Russian-developed tetrapeptide that enters nerve cell nuclei to regulate gene expression, studied for neuroregeneration after injury and cardiac tissue protection. Research dose: 5–10 mg daily x 10 days. Half-life: not established. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mg1Bio Longevity Labs Best $/mg
$59.47
$69.97Save $10.50
20mg vial
$3.50/mg
99%+ purityTested May 2026
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Rankings independent · Research use only
Synthetic tetrapeptide (Ala-Glu-Asp-Pro) Khavinson bioregulatory peptide with tissue-specific regulatory activity in cortical and peripheral nerve tissue. Penetrates cell nuclei, modulates gene expres
Where to Buy Cortagen
COA-verified vendors · Use code PEPTIDEX for up to 20% off
* Prices for research peptide acquisition. Not therapeutic products.
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
Bio Longevity LabsTriple-Tested | 99%+ | $69.9720 mg | $59.47Save 15% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
Bio Longevity LabsTriple-Tested
$69.97 · 20 mg$59.47−15%
Use code PEPTIDEX for 15% off at Bio Longevity Labs.
* Research vendor — verify your regional regulations before purchase.
Shop at Bio Longevity Labs§ Mechanism of Action
Synthetic tetrapeptide (Ala-Glu-Asp-Pro) Khavinson bioregulatory peptide with tissue-specific regulatory activity in cortical and peripheral nerve tissue. Penetrates cell nuclei, modulates gene expression profiles associated with neuroregeneration, and stimulates differentiation of neuronal progenitor cells. Also documented with cardioprotective effects via modulation of cardiac gene expression.
§ Primary Benefits
- 1Neuroregeneration
- 2peripheral nerve repair
- 3cardiac protection
- 4anti-aging
§ Clinical Evidence
Cortagen: cellular and molecular mechanisms of neuroprotection
Khavinson et al.: Cortagen demonstrates neuroprotective effects in a rat cortical neuron ischemia model by modulating gene expression and reducing apoptosis in damaged neuronal tissue.
PreclinicalShort peptide regulation of cardiac gene expression
Khavinson et al.: Cortagen modulates cardiac gene expression and reduces myocardial injury markers in rodent ischemia models, suggesting a cardioprotective role.
Preclinical§ Safety Profile
⚠ PRECLINICAL RESEARCH ONLY. Based entirely on Khavinson group publications. No Western clinical trials. Not FDA-approved. Research only. Limited reproducibility data outside the originating research group.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range5000–10000 mcg
FrequencyDaily x 10 days
Khavinson peptide protocol: short-course administration 1–2x per year. No validated Western protocol.
§ Expected Outcomes
Week 1
Neuroprotective marker changes in preclinical models
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Injection site reaction | Rare | mild |
Where to Source Cortagen for Research
Finding verified, high-purity Cortagen requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified Cortagen✓ Third-party tested·✓ US shipping·✓ COA on every batch
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Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
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§ About the Author Verified
PeptiDex Research
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