COMPOUNDNAD+
ALIASNicotinamide Adenine Dinucleotide
CLASSCoenzyme / Metabolic Cofactor
HALF-LIFE~1-2 hours (IV)
MW663.4 Da
FDA STATUSNot approved (dietary supplement forms available)
BEST PRICE$0.11/mg (Amino Club + PEPTIDEX)
LAST VERIFIEDMay 2026
NAD+
Last reviewed June 3, 2026
Also known as: Nicotinamide Adenine Dinucleotide, NAD Plus, Beta-Nicotinamide Adenine Dinucleotide
Quick Answer
NAD+ (nicotinamide adenine dinucleotide) is the central coenzyme in cellular energy metabolism — research by Sinclair et al. has demonstrated its role in sirtuin activation, DNA repair, and age-related decline. I've been tracking NAD+ precursor and injectable research for over two years. For sourcing, I verify COAs across vendors and use code PEPTIDEX at Amino Club for 20% off ($55.99/500mg vial). Research use only.
Where to Source
Ranked by $/mgSourcing data for NAD+ is updating.
We verify new listings weekly — check back soon.
Where to Source
Ranked by $/mgSourcing data for NAD+ is updating.
We verify new listings weekly — check back soon.
NAD+ is a critical coenzyme in every cell, essential for mitochondrial energy production (oxidative phosphorylation), DNA repair via PARP and sirtuin activation, and circadian rhythm regulation. Level
Where to Buy NAD+
COA-verified vendors · Use code PEPTIDEX for up to 20% off
Verified pricing for NAD+ is not yet available in our database. Browse all COA-verified vendors on our price comparison tool, or check individual vendor pages.
Compare All Vendors§ Mechanism of Action
NAD+ is a critical coenzyme in every cell, essential for mitochondrial energy production (oxidative phosphorylation), DNA repair via PARP and sirtuin activation, and circadian rhythm regulation. Levels decline ~50% between ages 40-60, contributing to metabolic dysfunction and aging.
§ Primary Benefits
- 1Cellular energy
- 2DNA repair
- 3longevity
§ Clinical Evidence
NAD+ decline is a driver of aging
Rajman et al. (Cell Metabolism): Comprehensive review demonstrating NAD+ decline as a hallmark of aging, with restoration improving mitochondrial function, stem cell renewal, and lifespan in animal models.
StrongNAD+ repletion improves mitochondrial and stem cell function
Zhang et al. (Science): NAD+ supplementation restores mitochondrial function in aged mice, improving muscle stem cell function and extending lifespan.
PreclinicalCD38 dictates age-related NAD decline and mitochondrial dysfunction
Camacho-Pereira et al. (Cell Metabolism): Identifies CD38 as the primary NAD-consuming enzyme that increases with age, explaining the progressive NAD+ decline.
PreclinicalNAD+ intermediates: NMN and NR clinical trial overview
Yoshino et al.: Review of human clinical trials for NAD+ precursors (NMN, NR) showing safe elevation of blood NAD+ levels with improvements in insulin sensitivity and muscle function.
ModerateLopinavir/ritonavir (ABT-378/r).
A study published in Expert opinion on pharmacotherapy investigating the effects and mechanisms.
PreclinicalNicotinamide riboside activates SIRT5 deacetylation.
A study published in The FEBS journal investigating the effects and mechanisms.
PreclinicalNAD(+) Metabolism and Diseases with Motor Dysfunction.
A study published in Genes investigating the effects and mechanisms.
PreclinicalMultiple domain interfaces mediate SARM1 autoinhibition.
A study published in Proceedings of the National Academy of Sciences of the United States of America investigating the effects and mechanisms.
PreclinicalProgresses in both basic research and clinical trials of NAD+ in Parkinson's disease.
A study published in Mechanisms of ageing and development investigating the effects and mechanisms.
ModerateAn Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.
A study published in Cell metabolism investigating the effects and mechanisms.
Preclinical§ Safety Profile
Generally well-tolerated. IV NAD+ infusions may cause chest tightness, nausea, and cramping during administration. Subcutaneous injection is better tolerated. Oral precursors (NMN, NR) have good safety profiles in clinical trials.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range50000–200000 mcg
FrequencyDaily
TimingMorning
Cycle Length4–12 weeks
BAC Water2 ml / 500mg vial
SubQ: 50-200mg daily. IV: 250-500mg over 2-4 hours. Start low — rapid NAD+ elevation can cause nausea and flushing. Oral precursors (NMN/NR) are an alternative.
§ Pharmacokinetics
⏱️ Half-Life: 4h
Plasma concentration over time§ Expected Outcomes
Week 1
Increased energy, mental clarity, reduced brain fog
Weeks 2–4
Improved exercise recovery, better sleep quality, mood stabilization
Month 2–3
Measurable improvements in metabolic markers, sustained energy throughout the day
Long-term
NAD+ level restoration; potential longevity benefits (animal data for lifespan extension)
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Nausea during infusion Dose-dependent; resolved by slowing infusion rate | ~30% (IV route) | moderate |
Flushing/warmth | ~20% of users | mild |
Chest tightness Transient during infusion, resolves within minutes | ~15% (IV route) | mild |
Injection site discomfort | ~10% (SubQ) | mild |
Where to Source NAD+ for Research
Finding verified, high-purity NAD+ requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified NAD+✓ Third-party tested·✓ US shipping·✓ COA on every batch
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NAD+ is the coenzyme I've been tracking the longest in the longevity space — Sinclair's lab work on sirtuin activation and the subsequent commercial explosion of NMN/NR precursors put this compound on the map, but injectable NAD+ research represents a different pharmacological approach entirely.
Amino Club batch ND0001 verified at 99.520% purity via Biogenica Labs. At $55.99/500mg after PEPTIDEX, it's competitively priced. At 663.4 Da, NAD+ is a well-characterized coenzyme — COA PDF linked below.
The research distinction matters: oral NMN/NR supplements rely on precursor conversion in the body. Injectable NAD+ bypasses that conversion entirely. The Braidy et al. 2019 review covers the metabolic landscape comprehensively. Whether direct NAD+ supplementation via injection produces clinically superior outcomes versus oral precursors remains an active research question.
📄 View COA: ND0001 (99.52% HPLC, 663.4 Da)Full disclosure — PEPTIDEX is my affiliate code. I track NAD+ across multiple vendors — pricing is competitive across the index.
§ Comparisons
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⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
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